xCELLigence

The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16.It is located inside a tissue culture incubator. Each of the three 16-well plate holders can be used independently under the RTCA Software. The RTCA DP Analyzer can automatically select wells for measurement and continuously transfer measured impedance data to the computer. Cell Index values, derived from the measured impedances, are continuously displayed on the Software user interface.

The RTCA DP Instrument is composed of three main components: • RTCA DP Analyzer • RTCA Control Unit • E-Plate 16 or CIM-Plates 16 * Highly flexible low throughput: Accommodates up to three E-Plates 16 or CIM-Plates 16 simultaneously

• Flexibility: Independent operation of the three 16 well plates by up to three different users
• Clear data presentation: 16-well graph shows individual Cell Index curves for all 16 wells
• Broad range of applications for cellular assays and cell invasion migration assays The xCELLigence System allows for label-free and real-time monitoring of cellular processes such as cell proliferation, cytotoxicity, adhesion, viability, invasion, and migration, using electronic cell sensor array technology. Real-time monitoring of cellular processes by the xCELLigence System offer distinct and important advantages over traditional end-point assays. First, the avoidance of labels allows for more physiologically relevant assays which save on time, labor, and resources. Second, a comprehensive representation of entire length of the assay is possible allowing the user to make informed decisions regarding the timing of certain manipulations or treatments . Finally, the actual kinetic response of the cells within an assay prior or subsequent to certain manipulations provides important information regarding the biological status of the cell such as cell growth, arrest, morphological changes and apoptosis.

CTC provide service of real-time monitoring of cellular processes such as cell proliferation, cytotoxicity, adhesion, viability, invasion, and migration, using electronic cell sensor array technology according to GLP (Good Manufacturing Practice) standard requirements.