Detection of Gilbert syndrome mutation ((TA) repeats in the UGT1A1 gene)

Gilbert or benign hyperbilirubinemia (nonhemolytic hyperbilirubinemia, unconjugated hyperbilirubinemia) is caused by changed number of the (TA) repeats in the promoter reagion of the UGT1A1 gene. Given mutation should be detected before treatment with irinotecan is started.

Contacts and Location

Contact 1	Linda Piekuse
Contact 2	Linda Gabrusenoka
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Organisational Unit	Rīga Stradiņš University Scientific Laboratory of Molecular Genetics - Latvia, Rīga

Description

Gilbert or benign hyperbilirubinemia (nonhemolytic hyperbilirubinemia, unconjugated hyperbilirubinemia) is caused by changed number of the (TA) repeats in the promoter reagion of the UGT1A1 gene. Given mutation should be detected before treatment with irinotecan is started.

Specification

Sample DNA or material for DNA isolation. (TA) repats in the UGT1A1 gene in patients DNA is detected by fluorescent PCR and fragment lenght analysis.

Accreditation

DGKL-RFB approved EQA sertificate for analysis of (TA) repats in the UGT1A1 (www.dgkl-rfb.de).

Delivery time

Negotiable. Depends on many factors: for example, number of samples.

Service ID #: 13

Last Updated: 10^th March, 2015

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