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Rīga Stradiņš University
Scientific Laboratory of Molecular Genetics - Latvia, Rīga
Gilbert or benign hyperbilirubinemia (nonhemolytic hyperbilirubinemia, unconjugated hyperbilirubinemia) is caused by changed number of the (TA) repeats in the promoter reagion of the UGT1A1 gene. Given mutation should be detected before treatment with irinotecan is started.
Sample DNA or material for DNA isolation. (TA) repats in the UGT1A1 gene in patients DNA is detected by fluorescent PCR and fragment lenght analysis.
Negotiable. Depends on many factors: for example, number of samples.